4.7 Article

Palladium-Catalyzed Oxidative Cyclization for the Synthesis of Indolyl/Pyrrolyl 3-Phosphonates

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 14, Pages 2267-2272

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600321

Keywords

C-H bond activation; imine-enamines; indoles; ketophosphonates; phosphonates; pyrroles

Funding

  1. CSIR
  2. IICB-CSIR [MLP-116, BSC-0115, BSC-0206]
  3. DST-India [CS-03/2013]
  4. BMS-USA

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Imino-/enaminophosphonates derived from amines and diethyl phenacyl phosphonates undergo oxidative cyclization via C-H bond activation catalyzed by palladium chloride to provide a convenient route for the synthesis of substituted indol-3-yl and pyrrol-3-yl phosphonates.

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