Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 24, Pages 4075-4084Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600883
Keywords
copper; diazo esters; beta-enamino esters; tandem reaction; terminal alkynes
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Funding
- CAS Interdisciplinary Innovation Team
- National Natural Science Foundation of China [21672199]
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An operationally simple and efficient copper-catalyzed three-component tandem reaction of terminal alkynes, diazo compounds and amines to yield -enamino esters is described. This straightforward protocol takes place rapidly with a wide range of substrates and gives the desired -enamino esters in good to excellent yields. Preliminary mechanistic studies suggested that the reaction probably proceeds through Cu-catalyzed formal C-H insertion to produce an alkynoate intermediate, which was then trapped by amines to give the -enamino esters.
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