Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 13, Pages 2179-2185Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600169
Keywords
1-aminoisoquinolines; base-promoted reaction; benzonitriles; cascade reaction; metal-free conditions
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Funding
- Innovative Medicines Initiative Joint Undertaking (CHEM21) [115360]
- European Union
- EFPIA
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Herein a practical and efficient protocol for preparing a range of aminoisoquinolines is reported. Various aminoisoquinolines were prepared in moderate to good yields from the corresponding 2-methylbenzonitriles and benzonitriles upon treatment with potassium tert-butoxide.
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