Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 358, Issue 15, Pages 2392-2397Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600050
Keywords
acetonitrile; cyanomethylation; sp(3) C-H bond activation; TEMPO; tetrahydroisoquinolines
Categories
Funding
- NSFC [21272001]
- Shanghai Education Committee [13ZZ014]
- Shanghai Jiao Tong University
Ask authors/readers for more resources
A novel method for the synthesis of cyanomethylated tetrahydroisoquinolines has been developed with mild reaction conditions, good yields and a broad substrate scope. Acetonitrile, a common solvent, is for the first time used as a pronucleophile for this type of two sp(3) C-H bonds cross-dehydrogenative coupling (CDC) reaction. A new oxidative system (CuCl2/TEMPO/Cs2CO3) has been established by our group, in which the mild TEMPO reagent was found to be a highly efficient oxidant.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available