Journal
BIOCONJUGATE CHEMISTRY
Volume 26, Issue 4, Pages 633-638Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bc5006202
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Funding
- Advantage West Midlands (AWM) Science City Initiative
- ERDF
- EPSRC DTA award
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- Australian Laureate Fellowship
- Engineering and Physical Sciences Research Council [1229943, 1358166] Funding Source: researchfish
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The in situ one-pot synthesis of peptidepolymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.
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