Journal
BIOCONJUGATE CHEMISTRY
Volume 27, Issue 2, Pages 329-340Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.5b00369
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Funding
- University of Southern California
- NIH [1R01DC009837, 1R21DE023410, 1R43AR067021-01A1, 1R43DE025524-01]
- Warner Chilcott
- Oxford NIHR Biomedical Research Unit
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A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has been created, including a novel linking strategy. The linking chemistry allows attachment of a diverse selection of dyes fluorescent in the visible to near-infrared range to any of the three clinically important heterocyclic bisphosphonate bone drugs (risedronate, zoledronate, and minodronate or their analogues). The resultant suite of conjugates offers multiple options to mix and match parent drug structure, fluorescence emission wavelength, relative bone affinity, and presence or absence of antiprenylation activity, for bone-related imaging applications.
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