4.8 Article

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

Journal

ADVANCED MATERIALS
Volume 28, Issue 32, Pages 6872-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600706

Keywords

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Funding

  1. Calbrain Program
  2. Natural Science Foundation of China [81471786]
  3. National Institutes of Health [NS092868]
  4. Department of Veterans Affairs [RX001218]
  5. South University of Science and Technology of China [FRG-SUSTC1501A-62]
  6. Recruitment Program of Global Youth Experts of China
  7. Shenzhen Key Lab [ZDSYS201505291525382]
  8. Shenzhen peacock program [KQTD20140630160825828]

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

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