Journal
ADVANCED MATERIALS
Volume 29, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201603702
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Funding
- Fonds der Chemischen Industrie (FCI) [661548]
- Deutsche Forschungs-gemeinschaft (DFG) [WU 787/2-1]
- Thuringer Ministerium fur Wirtschaft, Wissenschaft und digitale Gesellschaft
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An amphiphilic Ru-containing block copolymer is used as a photoactivated polymetallodrug for anticancer phototherapy. The block copolymer self-assembles into nanoparticles, which can accumulate at tumor sites in a mouse model. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic O-1(2), both of which can inhibit tumor growth.
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