4.8 Article

Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array

Journal

ADVANCED MATERIALS
Volume 28, Issue 18, Pages 3543-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600247

Keywords

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Funding

  1. National Natural Science Foundation of China [21475049, 31471257, 21275060]
  2. National Basic Research Program of China [2011CB910403]
  3. Directorate For Engineering
  4. Div Of Chem, Bioeng, Env, & Transp Sys [1547791] Funding Source: National Science Foundation
  5. Div Of Chem, Bioeng, Env, & Transp Sys
  6. Directorate For Engineering [1547806] Funding Source: National Science Foundation

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Heterogeneous 3D cell microenvironment arrays are rapidly assembled by combining surface-wettability-guided assembly and microdroplet-array-based operations. This approach enables precise control over individual shapes, sizes, chemical concentrations, cell density, and 3D spatial distribution of multiple components. This technique provides a cost-effective solution to meet the increasing demand of stem cell research, tissue engineering, and drug screening.

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