Journal
BIOCONJUGATE CHEMISTRY
Volume 26, Issue 10, Pages 2021-2024Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.5b00463
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Funding
- National Institutes of Health [PHS GM100962]
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A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine and two cholic acid molecules and found to have antifungal activities approaching that of the native drug. However, in sharp contrast to AmB, the hemolytic activity and the cytotoxcity of this conjugate toward HEK293 T cells have been dramatically reduced.
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