Journal
ADVANCED MATERIALS
Volume 28, Issue 39, Pages 8760-8765Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601191
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Funding
- Singapore National Research Foundation [R279-000-444-281]
- National University of Singapore [R279-000-415-112]
- Institute of Materials Research and Engineering of Singapore [IMRE/14-8P1110]
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Detection of damage to the blood-brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.
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