Journal
ADVANCED MATERIALS
Volume 28, Issue 33, Pages 7129-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601902
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Funding
- National Basic Research Programs of China (973 Program) [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51222203, 51132006]
- Juangsu Natural Science Fund for Distinguished Young Scholars [BK20130005]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.
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