Journal
ADVANCED MATERIALS
Volume 28, Issue 36, Pages 7962-7969Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600634
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Funding
- National Institutes of Health [R24 EY022025-01]
- National Science Foundation [DMR-1210417]
- Defense Advanced Research Projects Agency (DARPA) [HR0011-13-2-0017]
- Marie-D. & Pierre Casimir-Lambert Fund (MIT)
- Ruth L. Kirschstein National Research Service Award [1F32CA177094-01]
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Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
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