Journal
ADVANCED MATERIALS
Volume 28, Issue 19, Pages 3662-3668Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201505681
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Funding
- Nanyang Technological University [M4081627.120]
- MOE [M4011559.120, RG133/15]
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An activatable photoacoustic nanoprobe based on a semiconducting oligomer with amplified brightness and pH-sensing capability is developed by taking advantage of nanodoping to simultaneously create both intraparticle photoinduced electron transfer and intramolecular protonation within a single particle. This organic nanoprobe permits non invasive real-time ratiometric photo acoustic imaging of pH in tumors in living mice through systemic administration at a relatively low dosage.
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