4.8 Article

Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

Journal

ADVANCED MATERIALS
Volume 28, Issue 30, Pages 6411-+

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201506460

Keywords

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Funding

  1. National Science Foundation of China [81571744, 81301257, 31371012, 81171448, U1505228]
  2. National Basic Research Program of China (863 Program) [2015AA020502]
  3. Science Foundation of Fujian Province [2014Y2004]
  4. Xiamen University [0260-ZK1029]

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A gadolinium-doped multi-shell up-conversion nanoparticle under 800 nm excitation is synthesized with a 10-fold fluorescence-intensity enhancement over that under 980 nm. The nanoformulations exhibit excellent photoacoustic/luminescence/magnetic resonance tri-modal imaging capabilities, enabling visualization of tumor morphology and microvessel distribution at a new imaging depth.

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