4.8 Article

Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells

Journal

ADVANCED MATERIALS
Volume 28, Issue 24, Pages 4891-4897

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600658

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Funding

  1. National Institutes of Health (NIH) [1DP2OD006672-01]
  2. Converging Research Center Program - Ministry of Science, ICT and Future Planning [NRF-2014M3C1A8048791]
  3. National Science Foundation Graduate Research Fellowship Program [DGE 1256260]
  4. National Science Foundation

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A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

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