4.8 Article

Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

Journal

ADVANCED MATERIALS
Volume 29, Issue 6, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201604894

Keywords

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Funding

  1. National Key Research Program of China [2016YFC0101200]
  2. National Natural Science Foundation of China [21572153, 81530057, 21321063]
  3. Key Program of Natural Science Foundation of the Jiangsu Educational Committee [15KJA310004]
  4. Suzhou Science and Technology Program [SYG201520]

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Photocross-linkable Au nanoparticles are prepared through surface decoration of photo-labile diazirine moieties. Both in vitro and in vivo studies indicate that the light-triggered cross-linking can dramatically shift the surface plasmon resonance of Au nanoparticles to near-infrared regions, which in consequence remarkably enhances their efficacy for photothermal therapy and photoacoustic imaging of tumors in vivo.

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