Journal
ADVANCED MATERIALS
Volume 29, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201604043
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Funding
- Sloan Research Fellowship, NC TraCS, NIH's Clinical and Translational Science Awards (CTSA, NIH) at UNC-CH [1UL1TR001111]
- National Science Foundation (NSF) through ASSIST Engineering Research Center at NC State [EEC-1160483, EFRI-1240438]
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A thrombin-responsive microneedle-based transcutaneous patch is developed by C. M. Gallippi, Y. Zhu, Z. Gu, and co-workers, as demonstrated in article 1604043. The anticoagulant drug heparin is loaded into the hyaluronic acid needles through a thrombin cleavable peptide linker. This heparin patch can sense the thrombin level in blood vessels and autoregulate blood coagulation in a long-term manner. Cover design credit: Yuqi Zhang.
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