Journal
ADVANCED MATERIALS
Volume 28, Issue 42, Pages 9341-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503799
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Funding
- NSFC [21322508, 21210004]
- China National Key Basic Research Program (973 Project) [2013CB934100, 2012CB224805]
- Program for New Century Excellent Talents in University (NCET)
- China Postdoctoral Science Foundation [2016T90333]
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Overcoming multidrug resistance is achieved by developing a novel drug-delivery-system paradigm based on azobenzene liposome and phosphatidylcholine-modified upconversion nanoparticle (UCNP) hybrid vesicles for controlled drug release using a nearinfrared (NIR) laser. Upon 980 nm light irradiation, the reversible photoisomerization of the azobenzene derivatives by simultaneous UV and visible light emitted from the UCNPs makes it possible to realize NIR-triggered release of the chemotherapeutic drug doxorubicin.
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