Journal
ADVANCED MATERIALS
Volume 28, Issue 37, Pages 8097-8129Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201602012
Keywords
cancer therapy; micro; nanoparticles; nanotechnology; nanomedicine; sonodynamic therapy
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Funding
- National Nature Science Foundation of China [51302293, 81425014]
- Zhengjiang Medical Key Talents, Natural Science Foundation of Shanghai [13ZR1463500]
- Shanghai Rising-Star Program [14QA1404100]
- Youth Innovation Promotion Association [2013169]
- Institute Hundred-Talent Program of SICCAS
- Development Fund for Shanghai Talents
- Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures [SKL201203]
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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.
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