Journal
ADVANCED MATERIALS
Volume 28, Issue 37, Pages 8234-8239Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600065
Keywords
lung cancer; methotrexate sodium; polymersomes; reduction-sensitive; targeted delivery
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Funding
- National Natural Science Foundation of China (NSFC) [51273139, 51473111, 51561135010]
- National Science Fund for Distinguished Young Scholars (NSFC) [51225302]
- major project of Jiangsu Province University Natural Science [14KJA150008]
- Ph.D. Programs Foundation of Ministry of Education of China [20133201110005]
- Jiangsu Higher Education Excellent Science and Technology Innovation Team Program
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Anisamide-functionalized reversibly crosslinked chimeric polymersomes emerge as an all-function-in-one nano platform for efficient loading and targeted delivery of methotrexate disodium, a potent water-soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor-growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall).
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