Journal
ADVANCED MATERIALS
Volume 28, Issue 36, Pages 7929-7935Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601643
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Funding
- 863 Program [2013AA032204]
- National Natural Science Foundation of China [21422502, 21372028]
- Beijing Nova Program [Z141102001814066]
- Beijing Talents Fund [2015000021223ZK20]
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A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
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