Journal
ADVANCED MATERIALS
Volume 28, Issue 43, Pages 9581-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201602173
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Funding
- National Natural Science Foundation of China [81521005, 81270047]
- National Basic Research Program of China [2013CB932704, 2012CB932502]
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A unique biomimetic drug-delivery system composed of 4T1-breast-cancercell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.
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