Journal
ADVANCED MATERIALS
Volume 28, Issue 39, Pages 8740-8748Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201602628
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Funding
- Projects of International Cooperation and Exchanges [2013DFB30360]
- National Science Foundations of China [81571815, 21422507, 21321003]
- 1,000 Young Talents program
- Beijing Municipal Natural Science Foundation [7152156]
- Science Foundation of China University of Petroleum (Beijing) [2462015YJRC009]
- PetroChina Innovation Foundation [2015D-5006-0401]
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A hierarchical, intrafibrillarly mineralized collagen (HIMC) is achieved through a selective mineralization progress in the collagenous gap regions mediated by poly(acrylic acid) with appropriate molecular weight. The associated topographical features directly correlate with nanomechanical heterogeneities of the HIMC to accommodate a broad range of external loads. Moreover, this hierarchically staggered nanostructure provides an optimized microenvironment to improve bone regeneration by instructing host cells.
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