Journal
ADVANCED MATERIALS
Volume 28, Issue 35, Pages 7703-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601754
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Funding
- Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- National Health and Medical Research Council [1078118]
- ARC [FL120100030]
- National Heart Foundation [CR11M6066]
- National Health and Medical Research Council of Australia [1078118] Funding Source: NHMRC
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Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for post-functionalization with targeting peptides specific to plaques.
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