Journal
ADVANCED MATERIALS
Volume 28, Issue 27, Pages 5553-5585Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201505376
Keywords
drug-delivery systems; H2O2; imaging probes; ROS responsiveness; theranostics
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Funding
- European Union [317304]
- Science Foundation Ireland (SFI)
- European Regional Development Fund [13/RC/2073]
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Reactive oxygen species (ROS) (H2O2, OCl-, (OH)-O-center dot, O-2(-)) are a family of reactive molecules that are generated intracellularly and are engaged in many biological processes. In physiological concentrations, ROS act as signaling molecules to a number of metabolic pathways; however, in excess they can be harmful to living organisms. Overproduction of ROS has been related to many pathophysiological conditions and a number of studies have been reported in elucidating their mechanism in these conditions. With the aim of harnessing this role, a number of imaging tools and therapeutic compounds have been developed. Here these imaging and therapeutic tools are reviewed and particularly those structures with ROS-sensitivity based on their biomedical applications and their functional groups. There is also a brief discussion about the method of preparation as well as the mechanism of action.
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