Journal
ADVANCED MATERIALS
Volume 28, Issue 34, Pages 7501-7507Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601976
Keywords
Phi29 packaging RNA; RNA nanoparticles; RNA nanotechnology; tetrahedrons; three-way junctions
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Funding
- NIH [U01CA151648, R01EB019036, P41GM103832, P50 GM103297, P01GM091743]
- DOD [W81XWH-15-1-0052]
- University of Kentucky Markey Cancer Center [P30 CA177558]
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RNA tetrahedral nanoparticles with two different sizes are successfully assembled by a one-pot bottom-up approach with high efficiency and thermal stability. The reported design principles can be extended to construct higher-order polyhedral RNA architectures for various applications such as targeted cancer imaging and therapy.
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