Journal
WORLD JOURNAL OF CLINICAL CASES
Volume 6, Issue 14, Pages 745-752Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.12998/wjcc.v6.i14.745
Keywords
Inflammatory bowel disease; Necroptosis; Inflammation; Colorectal cancer; Intestinal infectious diseases; Drug therapy; Receptor interacting protein kinase 1 inhibitor
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Funding
- Ministry of Zhejiang Province of China [WKJ-ZJ-1516]
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For a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, inducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis of inflammatory bowel disease (IBD) and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD.
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