Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 10, Issue 10, Pages 317-327Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v10.i10.317
Keywords
Oncogenesis; Intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm; Pancreatic ductal adenocarcinoma; Pancreatic intraepithelial neoplasm; KRAS; Carcinogenesis; Pancreatic cancer; Intraductal tubulopapillary neoplasm
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Funding
- Associazione Italiana Ricerca sul Cancro [12182]
- Cassini Project
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Pancreatic cancer is a lethal malignancy, whose precursor lesions are pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm. To better understand the biology of pancreatic cancer, it is fundamental to know its precursors and to study the mechanisms of carcinogenesis. Each of these precursors displays peculiar histological features, as well as specific molecular alterations. Starting from such pre-invasive lesions, this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer, with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.
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