Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 26, Issue 19, Pages 3244-3249Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201505260
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Funding
- College of Engineering and Science, Victoria University, Australia
- MINECO, Spain [MAT2014-53500-R]
- FT [130100345]
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Physical delivery of anticancer drugs in controlled anatomic locations can complement the advances being made in chemo-selective therapies. To this end, an optical fiber catheter is coated in a thin layer of metal organic framework UiO-66 and the anticancer drug 5-Fluorouracil (5-FU) is deposited within the pores. Delivery of light of appropriate wavelength through the fiber catheter is found to trigger the release of 5-FU on demand, offering a new route to localized drug administration. The system exhibits great potential with as much as 110 x 10(-6) M of 5-FU delivered within 1 min from one fiber.
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