Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 26, Issue 45, Pages 8231-8242Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201603776
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Funding
- National Natural Science Foundation of China [51272299, 51273040, 51473033]
- Project of the Shanghai Committee of Science and Technology [13JC1400300]
- Fundamental Research Funds for the Central Universities
- DHU Distinguished Young Professor Program
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The ideal theranostic nanoplatform for tumors is a single nanoparticle that has a single semiconductor or metal component and contains all multimodel imaging and therapy abilities. The design and preparation of such a nanoparticle remains a serious challenge. Here, with FeS2 as a model of a semiconductor, the tuning of vacancy concentrations for obtaining all-in-one type FeS2 nanoparticles is reported. FeS2 nanoparticles with size of approximate to 30 nm have decreased photoabsorption intensity from the visible to near-infrared (NIR) region, due to a low S vacancy concentration. By tuning their shape/size and then enhancing the S vacancy concentration, the photoabsorption intensity of FeS2 nanoparticles with size of approximate to 350 nm (FeS2-350) goes up with the increase of the wavelength from 550 to 950 nm, conferring the high NIR photothermal effect for thermal imaging. Furthermore, this nanoparticle has excellent magnetic properties for T-2-weighted magnetic resonance imaging (MRI). Subsequently, FeS2-350 phosphate buffer saline (PBS) dispersion is injected into the tumor-bearing mice. Under the irradiation of 915-nm laser, the tumor can be ablated and the metastasis lesions in liver suffer significant inhibition. Therefore, FeS2-350 has great potential to be used as novel all-in-one multifunctional theranostic nanoagents for MRI and NIR dual-modal imaging guided NIR-photothermal ablation therapy (PAT) of tumors.
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