Journal
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 15, Issue 1, Pages 95-103Publisher
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2018.11.007
Keywords
Microencapsulation; Polyethylene imine; Poly L-lysine; Alginic acid; Poly electrolyte complexes; Extrusion
Categories
Funding
- Shahid Beheshti University of Medical Sciences [7026]
Ask authors/readers for more resources
In past decades, alginate-based multilayer microcapsules have been given important attention in various pharmaceutical investigations. Alginate-poly 1 lysine-alginate (APA) is studied the most. Due to the similarity between the structure of polyethyleneimine (PEI) and poly-L-lysine (PLL) and also lower price of PEI than PLL, this study was conducted to compare the efficacy of linear (LPEI) and branch (BPEI) forms of PEI with PLL as covering layers in fabrication of microcapsules. The microcapsules were fabricated using electrostatic bead generator and their shape/size, surface roughness, mechanical strength, and interlayer interactions were also investigated using optical microscopy, AFM, explosion test and FTIR, respectively. Furthermore, cytotoxicity was evaluated by comparing the two anionic final covering layers alginate (Alg) and sodium cellulose sulphate (NCS) using MTT test. BPEI was excluded from the rest of the study due to its less capacity to strengthen the microcapsules and also the aggregation of the resultant alginate-BPEI-alginate microcapsules, while LPEI showed properties similar to PLL. MTT test also showed that NCS has no superiority over Alg as final covering layer. Therefore, it is concluded that, LPEI could be considered as a more cost effective alternative to PLL and a promising subject for future studies. (C) 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available