Journal
CANCERS
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/cancers11010024
Keywords
Obesity; low-grade inflammation; liver and colon cancer; IL-6 and TNF; signaling
Categories
Funding
- DFG [KFO 286 RP5]
- German Cancer Aid foundation
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Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNF alpha and IL-6 signaling in hepatocellular carcinoma and colorectal cancers.
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