Journal
CANCERS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/cancers10110440
Keywords
long non-coding RNA (lncRNA); lncRNA Urothelial Cancer Associated 1 (UCA1); colorectal cancer (CRC); competing endogenous RNAs (ceRNA)
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Funding
- Institut National de la Sante et de la Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS)
- la Ligue Nationale contre le Cancer (Committee 59) [R17037EE - RAB17005EEA]
- la Ligue Nationale contre le Cancer (Committee 62)
- la Ligue Nationale contre le Cancer (Committee 80)
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Colorectal cancers have become the second leading cause of cancer-related deaths. In particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer are a major challenge for chemotherapy treatment. Accumulating evidence shows that long non-coding (lncRNAs) are involved in the initiation, progression, and metastasis of cancer. We here discuss the epigenetic mechanisms through which lncRNAs regulate gene expression in cancer cells. In the second part of this review, we focus on the role of lncRNA Urothelial Cancer Associated 1 (UCA1) to integrate research in different types of cancer in order to decipher its putative function and mechanism of regulation in colorectal cancer cells. UCA1 is highly expressed in cancer cells and mediates transcriptional regulation on an epigenetic level through the interaction with chromatin modifiers, by direct regulation via chromatin looping and/or by sponging the action of a diversity of miRNAs. Furthermore, we discuss the role of UCA1 in the regulation of cell cycle progression and its relation to chemoresistance in colorectal cancer cells.
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