Journal
JOURNAL OF CLINICAL MEDICINE
Volume 7, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/jcm7120477
Keywords
exercise; physical fitness; aerobic fitness; physical function; pulse wave velocity; autoimmune diseases; vascular health; atherosclerosis; lupus; inflammatory disease
Categories
Funding
- Fundacion para la Investigacion Biosanitaria de Andalucia Oriental [PI-0525-2016]
- Ilustre Colegio Oficial de Medicos de Granada (Premios de Investigacion)
- Spanish Ministry of Education [FPU15/00002]
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This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions x 75 min/week) between 40-75% of the individual's heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TENT-alpha], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI -0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-alpha, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.
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