Journal
BIOCHIMIE
Volume 117, Issue -, Pages 15-21Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2015.03.001
Keywords
Ribonucleoprotein complex; RNA-binding protein; Long noncoding RNA
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Funding
- National Institute on Aging Intramural Research Program, National Institutes of Health
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Most RNAs transcribed in mammalian cells lack protein-coding sequences. Among them is a vast family of long (>200 nt) noncoding (lnc)RNAs. LncRNAs can modulate cellular protein expression patterns by influencing the transcription of many genes, the post-transcriptional fate of mRNAs and ncRNAs, and the turnover and localization of proteins. Given the broad impact of lncRNAs on gene regulation, there is escalating interest in elucidating the mechanisms that govern the steady-state levels of lncRNAs. In this review, we summarize our current knowledge of the factors and methanisms that modulate mammalian lncRNA stability. (C) Published by Elsevier B.V.
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