Journal
CHEMISTRYSELECT
Volume 4, Issue 1, Pages 285-297Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201802927
Keywords
Coumarins; HepG2 cell lines; Molecular docking; Protein binding; Pyrazolo[1; 5-a]pyridine
Categories
Funding
- UGC
- University Grant Commission (UGC) New Delhi
Ask authors/readers for more resources
The reaction of a multi-substituted pyrazole 1 with aryl or heteroaryl aldehydes and active methylene compounds afford unexpected pyrazolo[1,5-a]pyridine derivatives 4(a-k). Mechanism for this unexpected reaction involving reactivity of the active methylene moiety with a neighboring endocyclic NH group is proposed and structure has been established by the NMR and single crystal X-ray diffraction studies. Moreover, all the newly synthesized compounds were tested for their anticancer activity against sixty human cell lines at NCI. Among all the compounds, three scaffolds 4d, 4 h and 4k showed enhancement in anticancer activity in comparison with remaining synthesized compounds. Interestingly compound 4k was found to highly active even at a five dose concentration. The IC50 values were determined against two cell lines MCF-7 and HepG2, the results obtained have shown promising effects against cancer cell lines. Further, the molecular docking studies revealed that substituted pyrazolo[1,5-a]pyridine derivatives are good candidates in the medicinal field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available