Journal
BIOCHIMIE
Volume 114, Issue -, Pages 147-154Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2015.02.005
Keywords
Fragile X syndrome; Fragile X mental retardation protein; Ribosome; Translation; RNA; Neuron
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Funding
- NIH Molecular Biophysics Training Grant [GM08326]
- NIH [R01 GM065265]
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Translational control is a common mechanism used to regulate gene expression and occur in bacteria to mammals. Typically in translational control, an RNA-binding protein binds to a unique sequence in the mRNA to regulate protein synthesis by the ribosomes. Alternatively, a protein may bind to or modify a translation factor to globally regulate protein synthesis by the cell. Here, we review translational control by the fragile X mental retardation protein (FMRP), the absence of which causes the neurological disease, fragile X syndrome (FXS). (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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