Journal
CHEMISTRYSELECT
Volume 3, Issue 48, Pages 13670-13674Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201801705
Keywords
Aldehydes; Domino; Nitroarenes; One-pot; Reductive amination; Secondary amines
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Funding
- CSIR, New Delhi, India
- CSIR, New Delhi [CSC-0108]
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We have developed a new and mild method for the direct one-pot reduction/reductive amination of nitroarenes with arylaldehydes using Fe/aq citric acid/montmorillonite K10 catalytic system under ambient conditions. This catalyst has excellent functional group compatibility and the reaction provides rapid access to a diverse range of secondary amines. Under the conditions, aromatic aldehydes are selectively reduced to benzyl alcohols in the presence of ketones. A concise and efficient approach to the synthesis of diverse range of 1,2-disubstituted benzimidazoles has also been accomplished for the first time from 1,2-dinitrobenzene and aromatic aldehydes using the above catalytic system. The method involves the domino nitro reduction/cyclization/reduction cascade.
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