Journal
ACS SENSORS
Volume 4, Issue 2, Pages 301-308Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.8b00682
Keywords
bifunctional theranostic nanoplatform; AuNC/SiO2/Apt nanoprobes; SERS imaging; photothermal therapy; cancer cells
Funding
- National Natural Science Foundation of China [21775070, 21424807]
- International Cooperation Foundation from Ministry of Science and Technology [2016YFE0130100]
- Jiangsu Province Postdoctoral Science Foundation [1501033B]
- China Postdoctoral Science Foundation [2015M581767]
- State Key Laboratory of Analytical Chemistry for Life Science Foundation [5431ZZXM1705]
- Fundamental Research Funds for the Central Universities [020514380082, 020514380127, 020514380115, 020514380102]
- Guangdong Provincial Key Platform and Major Scientific Research Projects for Colleges and Universities [2015KCXTD029]
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The combination of surface-enhanced Raman scattering (SERS) imaging technology with near-infrared (NIR) light-triggered photothermal therapy is of utmost importance to develop novel theranostic platforms. Herein, an aptamer-conjugated Au nanocage/SiO2 (AuNC/SiO2/Apt) core-shell Raman nanoprobe has been rationally designed as the bifunctional theranostic platform to fulfill this task. In this theranostic system, the Raman-labeled Au nanocage (AuNC) was encapsulated into a bioinert shell of SiO2, followed by conjugating aptamer AS1411 as the target-recognition moiety. AuNC served as the SERS-active and photo-thermal substrate due to its large free volume, built-in plasmon effect, and NIR photothermal capacity, while the SiO2 coating endowed the nanoprobes with good stability and biocompatibility, as well as abundant anchoring sites for surface functionalization. Considering their prominent SERS and photothermal properties, the application potential of the AuNC/SiO2/Apt nanoprobes was investigated. The proposed nanoprobes could be applied to targeted detection and SERS imaging of nucleolin-overexpressing cancer cells (MCF-7 cells as the model) from normal cells and also exhibited acceptable photothermal efficacy without systematic toxicity. This theranostic nanoplatform provided a possible opportunity for in situ diagnosis and noninvasive treatment of cancer cells by SERS imaging-guided photothermal therapy.
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