Journal
MOLECULAR THERAPY-ONCOLYTICS
Volume 12, Issue -, Pages 173-194Publisher
CELL PRESS
DOI: 10.1016/j.omto.2018.12.011
Keywords
-
Categories
Funding
- American Cancer Society [RSG-18-105-01-RMC]
- Elsa U. Pardee Foundation
- IU Simon Cancer Center
- NCI [F31-CA213731-01A1]
Ask authors/readers for more resources
MicroRNAs (miRNA) are small non-coding RNAs (similar to 22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29's functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available