Journal
FOOD BIOSCIENCE
Volume 28, Issue -, Pages 42-48Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2019.01.002
Keywords
Capparis spinosa; Seeds; Phenolic compounds; Nephroprotoxicity; Hepatotoxicity; Antifibrotic activity
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Funding
- Ministry of Higher Education and Scientific Research, Tunisia
- Faculty of Sciences of Gafsa (University of Gafsa, Tunisia)
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The phenolic compound content and the beneficial effects of Capparis spinosa seed extracts (CSSE) against the toxicity induced using cisplatin and CCl4 treatment were studied. The amounts of total phenolics, flavonoids and condensed tannins were 83 mg gallic acid equivalents, similar to 92 mg rutin equivalents, and 1 mg tannic acid equivalents/g d.w., respectively. Results showed that CSSE pretreatment restored the higher content of serum creatinine, urea and uric acid, and increased activities of aspartate aminotransferase, and alanine aminotransferase induced by cisplatin and CCl4 treatment. Furthermore, CSSE pretreatment decreased the protein carbonyls and malondialdehyde, and increased the activities of superoxide dismutase, catalase, and glutathione peroxidase. Histopathological studies confirmed that CSSE decreased the degree of tissues fibrosis. The results obtained confirmed the potential nutritional and medicinal benefits of C. spinosa and highlighted the potential use of the seeds as a source of bioantioxidants for the food and pharmaceutical industries.
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