Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 26, Issue 26, Pages 4749-4759Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201600031
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Funding
- National Natural Science Foundation of China [21301121, 81070491]
- Scientific Research Base Development Program of the Beijing Municipal Commission of Education [KM201410028008]
- Beijing Municipal Science and Technology Commission [Z131103002813097]
- Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality [IDHT20140512]
- National Science and Technology Support Program [2013BAI12B01]
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Photothermal therapy (PTT), a new, noninvasive treatment measure, has recently drawn much attention. However, due to the limited penetration depth of near-infrared (NIR) light, PTT is focused on treating superficial tumors. Improving the depth of the therapeutic effect is a bottleneck for successful PTT. To solve this problem, a new kind of nanoplatform (Nanogel+phenylethynesulfonamide (PES)) is fabricated by using a thermo-responsive polymer shell (poly(N-isopropylacrylamide-co-acrylic acid) to encapsulate 2-PES, an effective heat shock protein 70 (HSP70) inhibitor, and poly(3,4-ethylenedioxythiophene), a widely used photothermal coupling agent. Upon NIR irradiation, PES can be released from the Nanogel+PES when a thermo-responsive phase transition occurs, which could restrain the function of HSP70 and reduces the cells' endurance to heat. In this way, a better therapeutic effect on deeper tissues is achieved with a relatively small rise in temperature. Therefore, with the advantages of the thermo-responsive photothermal effect, coupled with the inhibition of HSP70, and minimal cytotoxicity, the Nanogel+PES appears to be a promising photothermal agent that can improve the depth of the PTT effect.
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