Journal
FRONTIERS IN GENETICS
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2018.00555
Keywords
miR-205-5p; PTEN; cisplatin resistance; ovarian cancer; AKT
Categories
Funding
- National Natural Science Foundation of China [81301084, 31400916]
- Doctoral Program of Higher Education of China [20130142120057]
- Bureau of Science and Technology of Wuhan Municipality [20150601010 10058]
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Cisplatin resistance is a major cause of treatment failure in advanced ovarian cancer. The limited evidence shows the paradoxical regulation of miR-205 on chemotherapy resistance in cancer. Herein, we found that miR-205-5p was enormously increased in cisplatin-resistant C13K ovarian cancer cells compared with its cisplatin-sensitive OV2008 parental cells using miRNA microarrays, which was further verified by quantitative PCR. Furthermore, we confirmed that inhibition of miR-205-5p upregulated PTEN and subsequently attenuated its downstream target p-AKT, which inversed C13K cells from cisplatin resistance to sensitivity. Our data suggest that miR-205-5p contributes to cisplatin resistance in C13K ovarian cancer cells may via targeting PTEN/AKT pathway.
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