Related references
Note: Only part of the references are listed.Metabolic Signaling to Epigenetic Alterations in Cancer
Jung-Ae Kim et al.
BIOMOLECULES & THERAPEUTICS (2018)
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Rui Su et al.
CELL (2018)
Metabolic regulation of chromatin modifications and gene expression
Juan Manuel Schvartzman et al.
JOURNAL OF CELL BIOLOGY (2018)
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Jingjing Chen et al.
NATURE GENETICS (2018)
Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation
Sharanya Sivanand et al.
TRENDS IN BIOCHEMICAL SCIENCES (2018)
Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2017)
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sharanya Sivanand et al.
MOLECULAR CELL (2017)
The impact of cellular metabolism on chromatin dynamics and epigenetics
Michael A. Reid et al.
NATURE CELL BIOLOGY (2017)
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
Oliver G. McDonald et al.
NATURE GENETICS (2017)
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rajesha Rupaimoole et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
C. C. Wong et al.
ONCOGENE (2017)
Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α
W. Wan et al.
ONCOGENE (2017)
Epigenetics in cancer: Fundamentals and Beyond
Subhankar Biswas et al.
PHARMACOLOGY & THERAPEUTICS (2017)
Chemical and structural biology of protein lysine deacetylases
Minoru Yoshida et al.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2017)
Epigenetic plasticity and the hallmarks of cancer
William A. Flavahan et al.
SCIENCE (2017)
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
Katharine Yen et al.
CANCER DISCOVERY (2017)
Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
Nabil Rabhi et al.
FRONTIERS IN ENDOCRINOLOGY (2017)
Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer
Keisuke Kosumi et al.
INTERNATIONAL JOURNAL OF CANCER (2016)
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells
Shinjiro Hino et al.
CANCER SCIENCE (2016)
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
Sita Kugel et al.
CELL (2016)
The Emerging Hallmarks of Cancer Metabolism
Natalya N. Pavlova et al.
CELL METABOLISM (2016)
Undercover: gene control by metabolites and metabolic enzymes
Jan A. van der Knaap et al.
GENES & DEVELOPMENT (2016)
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Jean-Pierre Etchegaray et al.
MOLECULAR CELL (2016)
Tumour hypoxia causes DNA hyper-methylation by reducing TET activity
Bernard Thienpont et al.
NATURE (2016)
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Marco Sciacovelli et al.
NATURE (2016)
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
Min Pan et al.
NATURE CELL BIOLOGY (2016)
Diet, microorganisms and their metabolites, and colon cancer
Stephen J. D. O'Keefe
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naive pluripotency by complementary mechanisms
Timothy Alexander Hore et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Epigenetic balance of gene expression by Polycomb and COMPASS families
Andrea Piunti et al.
SCIENCE (2016)
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Gregory V. Kryukov et al.
SCIENCE (2016)
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V. Liberti et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
Eoin McDonnell et al.
CELL REPORTS (2016)
Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer
Ran Zhao et al.
EBIOMEDICINE (2016)
Metabolic control of epigenetics in cancer
Adam Kinnaird et al.
NATURE REVIEWS CANCER (2016)
Metabolic Regulation of Histone Post-Translational Modifications
Jing Fan et al.
ACS CHEMICAL BIOLOGY (2015)
Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells
Akihisa Sakamoto et al.
CANCER RESEARCH (2015)
L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation
Waldemar Wagner et al.
CELL COMMUNICATION AND SIGNALING (2015)
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
Samantha J. Mentch et al.
CELL METABOLISM (2015)
Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells
Arieh Moussaieff et al.
CELL METABOLISM (2015)
Hypoxia Induces Production of L-2-Hydroxyglutarate
Andrew M. Intlekofer et al.
CELL METABOLISM (2015)
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Federico Pietrocola et al.
CELL METABOLISM (2015)
NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
Carles Canto et al.
CELL METABOLISM (2015)
Sirtuins and the Metabolic Hurdles in Cancer
Natalie J. German et al.
CURRENT BIOLOGY (2015)
Histone demethylases in chromatin biology and beyond
Emilia Dimitrova et al.
EMBO REPORTS (2015)
Chromatin remodeling and bivalent histone modifications in embryonic stem cells
Arigela Harikumar et al.
EMBO REPORTS (2015)
Targeting of cancer stem cells by inhibitors of DNA and histone methylation
Richard L. Momparler et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2015)
Oncometabolites: tailoring our genes
Stefan Nowicki et al.
FEBS JOURNAL (2015)
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
Joshua C. Black et al.
GENES & DEVELOPMENT (2015)
Reciprocal Modulation of Histone Deacetylase Inhibitors Sodium Butyrate and Trichostatin A on the Energy Metabolism of Breast Cancer Cells
Mariana Figueiredo Rodrigues et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2015)
A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors
Yi-Chao Zheng et al.
MEDICINAL RESEARCH REVIEWS (2015)
Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism
Seung Min Jeong et al.
MOLECULES AND CELLS (2015)
Epithelial-mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation
Linna Li et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells
Luyuan Li et al.
PLOS ONE (2015)
SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3
Filipa Quintela Vieira et al.
ONCOTARGET (2015)
Glycolytic metabolism influences global chromatin structure
Xue-Song Liu et al.
ONCOTARGET (2015)
New insights on chromatin modifiers and histone post-translational modifications in renal cell tumours
Marcia Vieira-Coimbra et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2015)
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Bryce W. Carey et al.
NATURE (2015)
50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
Eric Verdin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
The multifaceted functions of sirtuins in cancer
Angeliki Chalkiadaki et al.
NATURE REVIEWS CANCER (2015)
A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra et al.
CELL (2014)
Acetate Dependence of Tumors
Sarah A. Comerford et al.
CELL (2014)
Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee et al.
CELL METABOLISM (2014)
Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan
Tobias Eisenberg et al.
CELL METABOLISM (2014)
β-hydroxybutyrate: Much more than a metabolite
John C. Newman et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2014)
SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?
Liane M. McGlynn et al.
EUROPEAN JOURNAL OF CANCER (2014)
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
Atsushi Terunuma et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
Hariharan Easwaran et al.
MOLECULAR CELL (2014)
Down-Regulation of Nicotinamide N-methyltransferase Induces Apoptosis in Human Breast Cancer Cells via the Mitochondria-Mediated Pathway
Jun Zhang et al.
PLOS ONE (2014)
BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells
Maud Privat et al.
PLOS ONE (2014)
NAD+ and sirtuins in aging and disease
Shin-ichiro Imai et al.
TRENDS IN CELL BIOLOGY (2014)
Connections between TET proteins and aberrant DNA modification in cancer
Yun Huang et al.
TRENDS IN GENETICS (2014)
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Edward Seto et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
Paula Lopez-Serra et al.
NATURE COMMUNICATIONS (2014)
L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Eun-Hee Shim et al.
CANCER DISCOVERY (2014)
Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1
Yuhong Lu et al.
CELL REPORTS (2014)
Epigenetic therapy of acute myeloid leukemia using 5-aza-2′-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation
Richard L. Momparler et al.
CLINICAL EPIGENETICS (2014)
Defects in mitochondrial metabolism and cancer
Edoardo Gaude et al.
CANCER & METABOLISM (2014)
Impact of acetylation on tumor metabolism
Di Zhao et al.
MOLECULAR & CELLULAR ONCOLOGY (2014)
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Seung Min Jeong et al.
CANCER CELL (2013)
SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
Eric Letouze et al.
CANCER CELL (2013)
Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
Chenfang Dong et al.
CANCER CELL (2013)
Phase I study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer
B. F. Chu et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)
Influence of Metabolism on Epigenetics and Disease
William G. Kaelin et al.
CELL (2013)
The histone deacetylase SIRT2 stabilizes Myc oncoproteins
P. Y. Liu et al.
CELL DEATH AND DIFFERENTIATION (2013)
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3/-catenin signaling
Juan Chen et al.
HEPATOLOGY (2013)
Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
Jessica L. Feldman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Histone Acetylation Regulates Intracellular pH
Matthew A. McBrian et al.
MOLECULAR CELL (2013)
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
Sakari Vanharanta et al.
NATURE MEDICINE (2013)
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
Christoph Plass et al.
NATURE REVIEWS GENETICS (2013)
Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation
Dongning Pan et al.
PLOS ONE (2013)
An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
Dan Rohle et al.
SCIENCE (2013)
Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang et al.
SCIENCE (2013)
Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
M. G. Thomas et al.
CELL DEATH & DISEASE (2013)
Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
J. Keith Killian et al.
CANCER DISCOVERY (2013)
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
Alexandra Borodovsky et al.
ONCOTARGET (2013)
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
Sevin Turcan et al.
ONCOTARGET (2013)
Cancer cell metabolism: implications for therapeutic targets
Miran Jang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
Secretory miRNAs as novel cancer biomarkers
Jian Zhang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2012)
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
Rob A. Cairns et al.
BLOOD (2012)
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression
Natalie E. Simpson et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
ATP-Citrate Lyase: A Key Player in Cancer Metabolism
Nousheen Zaidi et al.
CANCER RESEARCH (2012)
Cancer Epigenetics: From Mechanism to Therapy
Mark A. Dawson et al.
CELL (2012)
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastian et al.
CELL (2012)
Connecting Threads: Epigenetics and Metabolism
Sayako Katada et al.
CELL (2012)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
Ketone bodies and two-compartment tumor metabolism Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells
Ubaldo E. Martinez-Outschoorn et al.
CELL CYCLE (2012)
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Anne Le et al.
CELL METABOLISM (2012)
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao et al.
GENES & DEVELOPMENT (2012)
Roles of microRNA on cancer cell metabolism
Bing Chen et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2012)
Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A
Imari Mimura et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Dallas R. Donohoe et al.
MOLECULAR CELL (2012)
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Joshua C. Black et al.
MOLECULAR CELL (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Peppi Koivunen et al.
NATURE (2012)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan et al.
NATURE (2012)
Dissecting the genomic complexity underlying medulloblastoma
David T. W. Jones et al.
NATURE (2012)
Comprehensive molecular characterization of human colon and rectal cancer
Donna M. Muzny et al.
NATURE (2012)
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Michael T. McCabe et al.
NATURE (2012)
Landscape of transcription in human cells
Sarah Djebali et al.
NATURE (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
Epigenetics and the environment: emerging patterns and implications
Robert Feil et al.
NATURE REVIEWS GENETICS (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
Tom Latham et al.
NUCLEIC ACIDS RESEARCH (2012)
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
Weibo Luo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
Dania Daye et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development
Roberto Gambari et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells
Sai-Wen Tang et al.
CARCINOGENESIS (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Ketones and lactate increase cancer cell stemness, driving recurrence, metastasis and poor clinical outcome in breast cancer
Ubaldo E. Martinez-Outschoorn et al.
CELL CYCLE (2011)
Regulation of chromatin by histone modifications
Andrew J. Bannister et al.
CELL RESEARCH (2011)
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Rasheduzzaman Chowdhury et al.
EMBO REPORTS (2011)
Mammalian Sirtuins and Energy Metabolism
Xiaoling Li et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)
The Lipogenesis Pathway as a Cancer Target
Hanley N. Abramson
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
Ling Cai et al.
MOLECULAR CELL (2011)
Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase
Wenqing Jiang et al.
MOLECULAR CELL (2011)
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
Lei Lv et al.
MOLECULAR CELL (2011)
Cancer epigenetics reaches mainstream oncology
Manuel Rodriguez-Paredes et al.
NATURE MEDICINE (2011)
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
Amparo Wolf et al.
NEUROBIOLOGY OF DISEASE (2011)
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
E. L. Bell et al.
ONCOGENE (2011)
Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells
Trenton L. Place et al.
PLOS ONE (2011)
Energy Metabolism in H460 Lung Cancer Cells: Effects of Histone Deacetylase Inhibitors
Nivea Dias Amoedo et al.
PLOS ONE (2011)
Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer
Mingquan Chen et al.
PLOS ONE (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
Patrick S. Ward et al.
CANCER CELL (2010)
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Maria E. Figueroa et al.
CANCER CELL (2010)
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
Jian-Bin Wang et al.
CANCER CELL (2010)
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Lei Zhong et al.
CELL (2010)
Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
Eva S. Schernhammer et al.
GUT (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation
Gema Alcarraz-Vizan et al.
METABOLOMICS (2010)
miR-23b*targets proline oxidase, a novel tumor suppressor protein in renal cancer
W. Liu et al.
ONCOGENE (2010)
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors
A. M. Schmitt et al.
ENDOCRINE-RELATED CANCER (2009)
Glucose Metabolism as a Target of Histone Deacetylase Inhibitors
Suzanne E. Wardell et al.
MOLECULAR ENDOCRINOLOGY (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen et al.
SCIENCE (2009)
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken et al.
NATURE REVIEWS CANCER (2009)
Tumor cell metabolism: Cancer's Achilles' heel
Guido Kroemer et al.
CANCER CELL (2008)
ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer
Toshiro Migita et al.
CANCER RESEARCH (2008)
Phase I Study of Epigenetic Modulation with 5-Azacytidine and Valproic Acid in Patients with Advanced Cancers
Fadi Braiteh et al.
CLINICAL CANCER RESEARCH (2008)
Causes and consequences of increased glucose metabolism of cancers
Robert J. Gillies et al.
JOURNAL OF NUCLEAR MEDICINE (2008)
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
Amber Buescher Johnson et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2008)
Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang et al.
NATURE GENETICS (2008)
Molecular origins of cancer: Epigenetics in cancer
Manel Esteller
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
Y. Wu et al.
ONCOGENE (2008)
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
M. Luz Martinez-Chantar et al.
HEPATOLOGY (2008)
L-type amino acid transporters LAT1 and LAT4 in cancer:: Uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo
Cathleen Haase et al.
JOURNAL OF NUCLEAR MEDICINE (2007)
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov et al.
NATURE REVIEWS CANCER (2007)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Mary M. Robinson et al.
BIOCHEMICAL JOURNAL (2007)
HIF-1 mediates the Warburg effect in clear cell renal carcinoma
Gregg L. Semenza
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)
Phenotypic plasticity and the epigenetics of human disease
Andrew P. Feinberg
NATURE (2007)
Histone acetyltransferase complexes: one size doesn't fit all
Kenneth K. Lee et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Development of histone deacetylase inhibitors for cancer treatment
Douglas Marchion et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
Nucleocytosolic acetyl-coenzyme A synthetase is required for histone acetylation and global transcription
Hidekazu Takahashi et al.
MOLECULAR CELL (2006)
Myc influences global chromatin structure
Paul S. Knoepfler et al.
EMBO JOURNAL (2006)
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
BE Bernstein et al.
CELL (2006)
PTEN promoter methylation in sporadic thyroid carcinomas
F Alvarez-Nunez et al.
THYROID (2006)
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
BC Fuchs et al.
SEMINARS IN CANCER BIOLOGY (2005)
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
XJ Yang
NUCLEIC ACIDS RESEARCH (2004)
Promoter methylation of the PTEN gene is a common molecular change in breast cancer
JM García et al.
GENES CHROMOSOMES & CANCER (2004)
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
R Hamamoto et al.
NATURE CELL BIOLOGY (2004)
Why do cancers have high aerobic glycolysis?
RA Gatenby et al.
NATURE REVIEWS CANCER (2004)
Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
RA Waterland et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Glucose metabolism in cancer - Evidence that demethylation events play a role in activating type II hexokinase gene expression
A Goel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Promoter methylation and silencing of PTEN in gastric carcinoma
YH Kang et al.
LABORATORY INVESTIGATION (2002)
Glycine N-methyltransferase deficiency:: A novel inborn error causing persistent isolated hypermethioninaemia
SH Mudd et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2001)
Mutations truncating the EP300 acetylase in human cancers
SA Gayther et al.
NATURE GENETICS (2000)