Key regulator of cellular metabolism, estrogen-related receptor alpha, a new therapeutic target in endocrine-related gynecological tumor

The estrogen-related receptor alpha (ERR alpha), is an orphan transcription factor. Recently, many studies have reported its regulatory mechanisms and transcriptional targets after identification. Therefore, it may be eligible to join the rank of other nuclear receptors that control almost all aspects of cell metabolism. Cellular metabolism reprogramming plays a key role in fueling malignant change. The purpose of this review was to demonstrate that the ERRa plays an important role in the association between gynecological endocrine-related tumors and energy metabolism. Furthermore, regulation of ERR alpha may represent a promising strategy to induce cellular metabolic vulnerability of cancer from different origins. Thus, a comprehensive understanding of current treatment strategies may be achieved.