Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 5, Issue 11, Pages 1428-1433Publisher
WILEY
DOI: 10.1002/acn3.656
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning, and the Republic of Korea [2016R1C1B2011815, 2016 M3C7A1914002]
- Lee Sueng Moon Research Fund of Seoul National University Hospital [3020170130]
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Interest in autoimmune encephalitis has been growing since the discovery of various autoimmune antibodies, such as N-methyl D-aspartate receptors antibody and leucine-rich glioma-inactivated 1 antibody. However, in contrast to autoimmune encephalitis associated with dysregulated adaptive immunity in the brain, the question of whether innate immunity-mediated autoinflammatory diseases exist in the brain has drawn much attention. Herein, we report a patient with microglia-dominant acute autoinflammatory encephalitis successfully treated with anakinra, an including interleukin-1 receptor blocker. In comparison to systemic autoinflammatory disease, we term this encephalitis cerebral autoinflammatory disease. Cerebral autoinflammatory disease could suggest new conceptual approaches to patients previously diagnosed with an unspecified encephalitis.
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