Journal
ACS CENTRAL SCIENCE
Volume 4, Issue 11, Pages 1559-1569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.8b00565
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Funding
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
- Program for Developing Next-generation Researchers (Japan Science and Technology Agency), KAKEN [18K15923]
- Konica Minolta Science and Technology Foundation
- Medical Research Encouragement Prize of The Japan Medical Association
- Uehara Memorial Foundation
- Kudo Foundation
- Takeda Science Foundation
- Nitto Foundation
- Kanae Foundaton for the Promotion of Medical Science
- Kowa Life Science Foundation
- Shimadzu Foundation
- Nakatani-Foundation
- Noguchi Institute
- Asahi Glass Foundation
- Ito Chubei Foundation
- Murata Science Foundation
- NATIONAL CANCER INSTITUTE [ZIABC011513] Funding Source: NIH RePORTER
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Photochemical reactions can dramatically alter physical characteristics of reacted molecules. In this study, we demonstrate that near-infrared (NIR) light induces an axial ligand-releasing reaction, which dramatically alters hydrophilicity of a silicon phthalocyanine derivative (IR700) dye leading to a change in the shape of the conjugate and its propensity to aggregate in aqueous solution. This photochemical reaction is proposed as a major mechanism of cell death induced by NIR photoimmunotherapy (NIR-PIT), which was recently developed as a molecularly targeted cancer therapy. Once the antibody-IR700 conjugate is bound to its target, activation by NIR light causes physical changes in the shape of antibody antigen complexes that are thought to induce physical stress within the cellular membrane leading to increases in transmembrane water flow that eventually lead to cell bursting and necrotic cell death.
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