Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 107, Issue -, Pages 97-135Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.04.017
Keywords
Poly(lactic acid); Poly(lactide); PLA; Stereocomplex; Biomedical applications; Pharmaceutical applications; Physical properties; Crystallization
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Upon blending enantiomeric poly(L-lactide) [i.e., poly(L-lactic acid) (PLLA)] and poly(D-lactide) (PDLA) [i.e., poly(D-lactic acid) (PDLA)] or synthesis of stereo block poly(lactide) [i.e., poly(lactic acid) (PLA)], a stereocomplex (SC) is formed. PLA SC has a higher melting temperature (or heat resistance), mechanical performance, and hydrolysis-resistance compared to those of neat PLLA and PDLA. Because of such effects, PLA SC has been extensively studied in terms of biomedical and pharmaceutical applications as well as commodity, industrial, and environmental applications. Stereocomplexation stabilizes and strengthens PLA-based hydrogel or nano particles for biomedical applications. Stereocomplexation increases the barrier property of PLA-based materials and thereby prolongs drug release from PLA based materials. In addition, PLA SC is attracting significant attention because it can act as a nucleating agent for the widely used biobased polymer PLLA and thereby the heat resistance of PLLA-based materials can be enhanced. Interestingly, a wide variety of SCs other than PLA SC are found to have been formed in the enantiomeric substituted PIA blends and stereo block substituted PIA polymers. In the present review article, a decade of progress in investigation of PIA SCs is summarized. (C) 2016 Elsevier B.V. All rights reserved.
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