Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 107, Issue -, Pages 176-191Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.05.020
Keywords
PIA; Micro-particles; Nano-particles; Fabrication methods; Drug delivery system
Categories
Funding
- Showalter Research Trust Fund
- National Institute of Health [CA129287, GM095879]
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Poly(D,L-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anticancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations. (C) 2016 Elsevier B.V. All rights reserved.
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